In 1806 François Isaac de Rivaz, a Swiss, designed the first internal combustion engine. He subsequently used it to develop the world's first vehicle to run on such an engine that used a mixture of hydrogen and oxygen to generate energy. The design was not very successful, as was the case with the British inventor, Samuel Brown, and the American inventor, Samuel Morey, who produced vehicles powered by clumsy internal combustion engines about 1826.

Etienne Lenoir produced the first successful stationary internal combustion engine in 1860, and within a few years, about four hundred were in operation in Paris. About 1863, Lenoir installed his engine in a vehicle. It seems to have been powered by city lighting-gas in bottles, and was said by Lenoir to have "travelled more slowly than a man could walk, with breakdowns being frequent."

Lenoir, in his patent of 1860, included the provision of a carburettor, so liquid fuel could be substituted for gas, particularly for mobile purposes in vehicles. Lenoir is said to have tested liquid fuel, such as alcohol, in his stationary engines; but it does not appear that he used them in his own vehicle. If he did, he most certainly did not use gasoline, as this was not well-known and was considered a waste product*

*source: Wikipedia, used with permission